Saffron effects on memory

Saffron effects on memory

Introduction : behavioral and electrophysiological studies show that saffron improves ethanol -induced memory impairment . Objective: In this study, the effects of intraperitoneal injection of crocin and saffron and its active ingredient saffranal on normal memory and memory impairment in rats with hyoscine was evaluated by Morris water maze

. Methods : The mice once a day for 5 days ( each session includes four experienced ) the maze randomly tested four quadrants of the pool . Materials and extracts except hyoscine ( 20 minutes ) one hour before the test was administered intraperitoneally . On the fifth day activity was conducted using an open box on animals . Results : saffron extract in doses ranging from 0.56 to 0.0025 kg did not find the platform as a whole .

Saffron effects on memory,Saffron extract

Only 0.005 kg dose of saffron over time will reduce the time to find the platform . Crocin at doses of 50 and 200 kg in total , especially on days 4 and 5 had no effect on the time to find the target platform . Safranal doses ranging from 0.75 -0.2 kg dose increased with increased time to find the platform . Aqueous extract and its active ingredient on memory impairment by low doses ( 1 mg kg ) and high ( 0.5 kg) were also studied hyoscine . Hyoscine reduces the harmful effects of low doses of saffron (both doses ) on the memory. Effects of different doses of crocin in the hyoscine group decreased by platform .

Safranal dose of 0.2 ml kg reduced the harmful effects of low doses of hyoscine . Materials and saffron effects on locomotor activity of rats was measured by an open box . Saffron extract and its active approximately dose-dependent decrease in locomotor activity in rats.

These compounds are used in combination with hyoscine decreased motor activity as a whole . Conclusion: These results indicate that saffron , crocin and saffranal but no effect on the normal memory reduces the effects of hyoscine -induced memory impairment . Saffron extract and crocin may be future promise in reducing drugs -related deterioration of learning and memory disorders such as Alzheimer ‘s disease or