Iranian researchers on the effect of saffron on lowering blood pressure
Researchers of Mashhad University of Medical Sciences in their research project succeeded in identifying the effect of saffron aqueous extract and its two compounds, including crocin and safranal, in lowering blood pressure.
This research was conducted by Dr. Mohsen Ayman Shahidi, Dr. Hossein Hosseinzadeh and Dr. Yaser Javadpour, faculty members of the Faculty of Pharmacy, Mashhad University of Medical Sciences.
In this study, the effect of saffron aqueous extract and its two compounds, crocin and safranal, in lowering blood pressure with normal blood pressure as well as blood pressure with the drug (deoxy corticosterone acetate) was investigated.
The researchers administered three doses of crocin (50 mg / kg, 100, 200), safranal (0.5, 0.5, 1 mg / kg) and aqueous extract (2.5, 5, 10 mg / kg) intravenously. Five groups of animals with normal or high blood pressure were injected and their effect on mean arterial blood pressure (MABP) and heart rate was evaluated.
The results showed that the aqueous extract of saffron, crocin and safranal reduced arterial blood pressure in a dose-dependent manner in animals with normal blood pressure and hypertension. For example, administration of 10 mg / kg aqueous extract, 1 mg / kg safranal, and 200 mg / kg crocin causes a decrease in blood pressure of 60.7 + – 60, 5.2 + – 50 and 3.8 + – 51 – 3 mmHg, respectively. Became arterial.
According to the results of this study, it can be said that the aqueous extract of saffron stigma has antihypertensive effects, which seems to be at least partly due to two effective compounds in the plant, namely crocin and safranal, and safranal in lowering blood pressure. Power has a greater effect than crocin.
Crocin and safranal are two active ingredients in saffron.
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