Saffron therapeutic effect on tumors
Tarbiat Modarres University School of Medicine researchers in a study to evaluate the effect of crocin and crocetin saffron on the expression of P53 and P27 in breast cancer tumors began.
According to Mehr News Agency, saffron not only as a spice, but also as a medicinal plant with various therapeutic uses, the attention. An important use for this plant has proven its role in the treatment of various cancers.
Mahshid Azizian – Master of Biochemistry in this regard, said crocetin and crocin of anti-tumor and anti-cancer effects of carotenoids of saffron that has been shown in various studies. However, the precise molecular mechanism of action of compounds to inhibit the cancer is still unclear.
He pointed to the increasing incidence of breast cancer in women, said breast cancer is the most common cancer in women 06 to 57 percent depending on the type of estrogen is also one of the causes of the imbalance between death and proliferation of cancer cell through the cell cycle. P35 is one of the most important gene involved in apoptosis and cell proliferation is also dependent kinases inhibitors P72 plus is also one of the activities leading to the inhibition of the cell cycle.
Azizian the objectives of the project, said: Since our previous study different effects on the activation of crocin and crocetin P12 in breast cancer tumors in rats was induced by UMN. In order to clarify the mechanism of this effect, P35 and P72 gene expression in the tumor and normal tissue RNA from rat NMU-induced breast cancer were female. The gene expression of P35 and P72 in the samples was determined using RCP-TR.
He described his findings as follows: The samples without treatment and treated with saffron carotenoids, P35 gene expression in patients with tumors of rats, but decreased expression in tumors treated with Krusin crocetin showed. Also, the reduction of P72 expression in rats treated with crocetin and crocin tumors than rats without tumor was observed.
At the end of Tarbiat Modarres University researcher said crocetin and crocin P72 expression in breast cancer tumors induced by NMU reduced their impact on the P35 was different, but the findings are consistent with previous data about P12.
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